It was 1862, and the American Egyptologist Edwin Smith had just made a fascinating discovery in Luxor, Egypt, the site of ancient Thebes.
This was no archaeological mystery unearthed from the country’s time-worn sands, however. Instead, Smith’s acquisition came from an Egyptian dealer, Mustafa Agha, who sold him an unusual papyrus that seemed to describe medical practices from Egypt’s Second Intermediate Period.
Smith kept the papyrus until his death in 1906, largely unaware of its contents, as his understanding of hieratic was limited and he was unable to translate it. After Smith’s passing, many of the items in his collection, including the mysterious papyrus, were given to the New York Historical Society by his daughter, where they quietly remained for several more years.
It wasn’t until 1920 that the ancient treatise came to the attention of the classical archaeologist and Egyptologist Caroline Ransom Williams, who brought it to the attention of noted archaeologist James Henry Breasted.
“The papyrus is probably the most valuable one owned by the Society,” Williams wrote to Breasted at the time, “and I am ready to waive my interest in it, in the hope that it may be published sooner and better than I could do it.” Recognized as the first chair in Egyptology and Oriental History in the United States at the University of Chicago, Breasted was immediately fascinated by the ancient text and set to work deciphering it.
One decade later, Breasted had finally completed the task of interpreting the obscure ancient document in its entirety, a translation of which was published in 1930. The result was a fundamental shift in our understanding of the ancient history of medical science and its early beginnings, revealing evidence for advanced medical knowledge in ancient Egypt as much as 1000 years before what scholars had commonly accepted at the time.
The Edwin Smith Papyrus: Obscure Origins and a Cliffhanger Ending
The document, known today as the Edwin Smith Papyrus, was cut into one-column pages at some point in the last century. It features Egyptian hieratic written in ink of two different colors: most of the text is black, while some portions with addenda to the primary document appear in red.

Little is known about the author of the papyrus, although scholars agree that the version that exists today is likely the work of a single scholar, and probably also represents a copy of an even older manuscript from Egypt’s Old Kingdom.
Several clues point to this possibility: despite the document’s physical age, scholars note the inclusion of archaic forms of Egyptian words and grammar, suggesting the papyrus is a copy of a much earlier document. Equally tantalizing is that the document ends in mid-sentence, suggesting that, in addition to being a copy, the surviving version is an incomplete work.
From Ancient Magic to Medical Science
Most intriguing of all is the information the document contains. Outlined in an illustrated survey of 48 case histories, the Edwin Smith Papyrus presents a remarkable ancient Egyptian perspective on various injuries and their treatments. Each case details a different region of the body and/or a specific organ and discusses each injury systematically, even including references to the original doctor’s notes on ailments “which I will treat,” suggesting a physician logging their diagnoses of conditions afflicting their patients.
From descriptions of human anatomy to treatments for bleeding, curing infections, and closing wounds, the medical knowledge outlined in the papyrus is remarkably advanced for the period in which it is believed to have originated. Additionally, discussions of medicines featured in the document reveal a level of understanding that exceeds that previously known to have existed at the time by a significant margin, even going beyond medicinal knowledge first recorded by the Greek physician Hippocrates, close to 1000 years later.
Perhaps most significant of all, the document’s precocious discussion of medical knowledge marks a significant shift away from the use of spells and incantations, which are widely believed to have been commonly used for the treatment of a variety of ailments during Egypt’s Old Kingdom. Although the Edwin Smith Papyrus does still contain some references to magic—there are eight magic spells that appear on its “verso” (back left-hand) side—it is believed that these magical references may have represented a sort of “last effort” in cases where all forms of medical treatment had proven ineffective.
This is significant, since the Edwin Smith Papyrus could represent more than just an example of ancient Egyptian medical knowledge that was well ahead of its time: it marks a fundamental shift away from traditional magical beliefs toward practical diagnosis and treatment, making it a record of one of the earliest major medical science advancements in the ancient Egyptian world.
A Textbook by the First Doctor?
Given the advanced knowledge detailed in the papyrus, one accepted theory about the document’s purpose is that it served as an early textbook, likely the result of examinations of battlefield injuries.
Considering the information the papyrus contains, James Henry Breasted even went so far as to speculate that the enigmatic document might have been authored by none other than Imhotep, the Egyptian architect and early physician believed to have created the first step pyramid built at Saqqara, at the direction of the third-dynasty pharaoh Djoser.
Given his noted role as a high priest and Old Kingdom physician, Imhotep is often considered one of history’s earliest known doctors, making him a good fit for the kind of medical knowledge found in the Edwin Smith papyrus. Still, there is no direct evidence linking the Old Kingdom scholar with the papyrus or its contents, and Breasted noted in his evaluation of the text that such connections were purely speculative on his part.
Fundamentally, while much of the document remains a mystery, the translation of the surviving version offers a rare glimpse into the surprisingly advanced medical knowledge that existed in ancient Egypt. Today, it represents just one of the many examples of advanced knowledge in Egypt’s Old Kingdom, which, over time, has gradually helped reshape our understanding of the ancient world.
Micah Hanks is the Editor-in-Chief and Co-Founder of The Debrief. A longtime reporter on science, defense, and technology with a focus on space and astronomy, he can be reached at micah@thedebrief.org. Follow him on X @MicahHanks, and at micahhanks.com.
