The placebo effect overlaps with other areas of your brain that are activated with treatments for depression, suggesting a brain could heal itself
The placebo effect overlaps with other areas of the brain that are activated with treatments for depression, suggesting a brain could heal itself (PC

New Research Suggests the Cure for Depression Could All Be in Your Head

The placebo effect, roughly defined as an effect where an individual’s brain believes a fake substance with no medicinal value actually works, has been an important aspect of popular psychology and popular culture for decades. It has given rise to several ethical debates too, as well as helpful plotlines for films or movies.

The placebo effect can be helpful in the drug development process too, as well as research in the area of pain management. While the placebo effect has been studied for decades, new research from the Massachusetts General Hospital hints at a deeper connection between the placebo effect and treatments for depression.

Background: Tricking the Brain and Current Treatments for Depression 

Recent research has revealed that there is a neurological area in the brain where the placebo effect occurs. With imaging studies, scientists have seen certain areas of the brain “light up” when the placebo effect is happening. Knowing where the placebo effect is activating the brain is important for scientists to better understand why and how this process happens. 

Similarly, scientists have also found certain areas of the brain that are stimulated when the subject is treated for depression. There are many treatments for depression, but one is Transcranial Magnetic Stimulation (TMS), part of a series of treatments that stimulate the brain with electric pulses. TMS is a non-invasive treatment for patients, working via a coil on the patient’s head that sends electromagnetic pulses to the brain. As TMS has been thoroughly researched for over 30 years, it’s become an FDA-approved treatment for helping with depression.

Analysis: A Cranial Overlap

In studying the areas of the brain affected by TMS, researchers at Massachusetts General Hospital found that some of those same areas also “lit up” for the placebo effect, publishing their findings in Molecular Psychiatry. The researchers believed that this overlap could account for some of the puzzling results of previous depression studies that included a placebo. According to lead researcher Emiliano Santarnecchi, director of the Precision Neuroscience and Neuromodulation Program at the hospital: “There is a significant effect when you do any form of brain stimulation intervention.” Because TMS is directly applied to a patient’s head, with loud clicks heard for each pulse, it’s easy for a patient to believe they are receiving treatment. Santarnechi added that the patient thinks: “‘Wow, they are really activating my brain,’ so you get a lot of expectation.”

Outlook: Expanded Placebo Effect

Because of the overlap within the brain, Santarnecchi and his team believe that the placebo effect could have bigger implications for depression treatments. “We think this is an important starting point for understanding the placebo effect in general, and learning how to modulate and harness it, including using it as a potential therapeutic tool by intentionally activating brain regions of the placebo network to elicit positive effects on symptoms.” Because depression affects around 14.8 million Americans every year, harnessing the power of this process could help millions of individuals be no longer dependent on medications or intense therapies, but heal themselves in a more natural way by tricking their own brains.

Kenna Castleberry is a staff writer at the Debrief and the Science Communicator at JILA (a partnership between the University of Colorado Boulder and NIST). She focuses on deep tech, the metaverse, and quantum technology. You can find more of her work at her website: